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NHL, however, is much less predictable than Hodgkin lymphoma and has a far greater predilection to disseminate to extranodal sites.
(We're just checking to see if you're reading carefully.The vast majority of relapses occur in the first 2 years after therapy.The risk of late relapse is higher in patients who manifest both indolent and aggressive histologies. While indolent NHL is responsive to immunotherapy, radiation therapy, and chemotherapy, a continuous rate of relapse is usually seen in advanced stages.Best of all, there's no additional cost to use cam-to-cam when you're in a private show., but if you need help, you should be able to talk to a human.In general, with modern treatment of patients with NHL, overall survival at 5 years is over 60%.
Of patients with aggressive NHL, more than 50% can be cured.
Most of the indolent types are nodular (or follicular) in morphology.
The aggressive type of NHL has a shorter natural history, but a significant number of these patients can be cured with intensive combination chemotherapy regimens.
Pelvic radiation therapy and large cumulative doses of cyclophosphamide have been associated with a high risk of permanent sterility. For as many as three decades after diagnosis, patients are at a significantly elevated risk for second primary cancers, especially the following:[1-3] Left ventricular dysfunction was a significant late effect in long-term survivors of high-grade NHL who received more than 200 mg/m² of doxorubicin.[4,5] Myelodysplastic syndrome and acute myelogenous leukemia are late complications of myeloablative therapy with autologous bone marrow or peripheral blood stem cell support, as well as conventional chemotherapy-containing alkylating agents.[1,6-13] Most of these patients show clonal hematopoiesis even before the transplantation, suggesting that the hematologic injury usually occurs during induction or reinduction chemotherapy.[8,14,15] With a median 10-year follow-up after autologous bone marrow transplantation (BMT) with conditioning using cyclophosphamide and total-body radiation therapy, in a series of 605 patients, the incidence of a second malignancy was 21%, and 10% of those were solid tumors. Successful pregnancies with children born free of congenital abnormalities have been reported in young women after autologous BMT. Some patients have osteopenia or osteoporosis at the start of therapy; bone density may worsen after therapy for lymphoma. A pathologist should be consulted before a biopsy because some studies require special preparation of tissue (e.g., frozen tissue).
Knowledge of cell surface markers and immunoglobulin and T-cell receptor gene rearrangements may help with diagnostic and therapeutic decisions.
NHL can be divided into two prognostic groups: the indolent lymphomas and the aggressive lymphomas.