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NHL, however, is much less predictable than Hodgkin lymphoma and has a far greater predilection to disseminate to extranodal sites.

(We're just checking to see if you're reading carefully.The vast majority of relapses occur in the first 2 years after therapy.The risk of late relapse is higher in patients who manifest both indolent and aggressive histologies.[4] While indolent NHL is responsive to immunotherapy, radiation therapy, and chemotherapy, a continuous rate of relapse is usually seen in advanced stages.Best of all, there's no additional cost to use cam-to-cam when you're in a private show., but if you need help, you should be able to talk to a human.In general, with modern treatment of patients with NHL, overall survival at 5 years is over 60%.

Of patients with aggressive NHL, more than 50% can be cured.

Most of the indolent types are nodular (or follicular) in morphology.

The aggressive type of NHL has a shorter natural history, but a significant number of these patients can be cured with intensive combination chemotherapy regimens.

Pelvic radiation therapy and large cumulative doses of cyclophosphamide have been associated with a high risk of permanent sterility.[1] For as many as three decades after diagnosis, patients are at a significantly elevated risk for second primary cancers, especially the following:[1-3] Left ventricular dysfunction was a significant late effect in long-term survivors of high-grade NHL who received more than 200 mg/m² of doxorubicin.[4,5] Myelodysplastic syndrome and acute myelogenous leukemia are late complications of myeloablative therapy with autologous bone marrow or peripheral blood stem cell support, as well as conventional chemotherapy-containing alkylating agents.[1,6-13] Most of these patients show clonal hematopoiesis even before the transplantation, suggesting that the hematologic injury usually occurs during induction or reinduction chemotherapy.[8,14,15] With a median 10-year follow-up after autologous bone marrow transplantation (BMT) with conditioning using cyclophosphamide and total-body radiation therapy, in a series of 605 patients, the incidence of a second malignancy was 21%, and 10% of those were solid tumors.[16] Successful pregnancies with children born free of congenital abnormalities have been reported in young women after autologous BMT.[17] Some patients have osteopenia or osteoporosis at the start of therapy; bone density may worsen after therapy for lymphoma.[18] A pathologist should be consulted before a biopsy because some studies require special preparation of tissue (e.g., frozen tissue).

Knowledge of cell surface markers and immunoglobulin and T-cell receptor gene rearrangements may help with diagnostic and therapeutic decisions.

NHL can be divided into two prognostic groups: the indolent lymphomas and the aggressive lymphomas.