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Centenarians may become the norm, rather than rarities who generate a headline in the local newspaper. On a verdant hillside in Marin County, California—home to hipsters and towering redwoods, the place to which the Golden Gate Bridge leads—sits the Buck Institute, the first private, independent research facility dedicated to extending the human life span.Since 1999, scientists and postdocs there have studied ways to make organisms live much longer, and with better health, than they naturally would.

Traditional research assumes the chronic later-life diseases that are among the nation’s leading killers—cardiovascular blockage, stroke, Alzheimer’s—arise individually and should be treated individually.

Late in 2013, Google brought its trove of cash into the game, founding a spin-off called the California Life Company (known as Calico) to specialize in longevity research.

Six months after Calico’s charter was announced, Craig Venter, the biotech entrepreneur who in the 1990s conducted a dramatic race against government laboratories to sequence the human genome, also founded a start-up that seeks ways to slow aging.

A graph of global life expectancy over time looks like an escalator rising smoothly.

The trend holds, in most years, in individual nations rich and poor; the whole world is riding the escalator.

If longer life expectancy simply leads to more years in which pensioners are disabled and demand expensive services, health-care costs may balloon as never before, while other social needs go unmet. If medical interventions to slow aging result in added years of reasonable fitness, life might extend in a sanguine manner, with most men and women living longer in good vigor, and also working longer, keeping pension and health-care subsidies under control.

Indeed, the most-exciting work being done in longevity science concerns making the later years vibrant, as opposed to simply adding time at the end.

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if not for eons—anthropology continuously pushes backward the time of human origin—life expectancy was short.

Projections of ever-longer life spans assume no incredible medical discoveries—rather, that the escalator ride simply continues.

If anti-aging drugs or genetic therapies are found, the climb could accelerate.

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